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5-HT2B receptor

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The correct title of this article is 5-HT2B receptor. It appears incorrectly here because of technical restrictions.


5-hydroxytryptamine (serotonin) receptor 2B
Identifiers
Symbol(s) HTR2B; 5-HT(2B); 5-HT2B
External IDs OMIM: 601122 MGI109323 Homologene55492
RNA expression pattern

250px

More reference expression data

Orthologs
Human Mouse Entrez 3357 15559 Ensembl ENSG00000135914 ENSMUSG00000026228 Uniprot P41595 Q7TNN4 Refseq NM_000867 (mRNA)
NP_000858 (protein)
NM_008311 (mRNA)
NP_032337 (protein)
Location Chr 2: 231.68 - 231.7 Mb Chr 1: 87.93 - 87.94 Mb
Pubmed search [1] [2]

5-hydroxytryptamine (serotonin) receptor 2B, also known as HTR2B, is a 5-HT2 receptor, but also denotes the human gene encoding it.[1]

Function Agonists Antagonists


See also

References

Further reading


  • Raymond JR, Mukhin YV, Gelasco A, et al. (2002). Multiplicity of mechanisms of serotonin receptor signal transduction.. Pharmacol. Ther. 92 (2-3): 179-212.
  • Bonhaus DW, Bach C, DeSouza A, et al. (1995). The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors.. Br. J. Pharmacol. 115 (4): 622-8.
  • Choi DS, Birraux G, Launay JM, Maroteaux L (1994). The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors.. FEBS Lett. 352 (3): 393-9.
  • Kursar JD, Nelson DL, Wainscott DB, Baez M (1994). Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.. Mol. Pharmacol. 46 (2): 227-34.
  • Schmuck K, Ullmer C, Engels P, Lübbert H (1994). Cloning and functional characterization of the human 5-HT2B serotonin receptor.. FEBS Lett. 342 (1): 85-90.
  • Launay JM, Birraux G, Bondoux D, et al. (1996). Ras involvement in signal transduction by the serotonin 5-HT2B receptor.. J. Biol. Chem. 271 (6): 3141-7.
  • Le Coniat M, Choi DS, Maroteaux L, et al. (1996). The 5-HT2B receptor gene maps to 2q36.3-2q37.1.. Genomics 32 (1): 172-3.
  • Kim SJ, Veenstra-VanderWeele J, Hanna GL, et al. (2000). Mutation screening of human 5-HT(2B)receptor gene in early-onset obsessive-compulsive disorder.. Mol. Cell. Probes 14 (1): 47-52.
  • Manivet P, Mouillet-Richard S, Callebert J, et al. (2000). PDZ-dependent activation of nitric-oxide synthases by the serotonin 2B receptor.. J. Biol. Chem. 275 (13): 9324-31.
  • Becamel C, Figge A, Poliak S, et al. (2001). Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.. J. Biol. Chem. 276 (16): 12974-82.
  • Manivet P, Schneider B, Smith JC, et al. (2002). The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis.. J. Biol. Chem. 277 (19): 17170-8.
  • Borman RA, Tilford NS, Harmer DW, et al. (2002). 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro.. Br. J. Pharmacol. 135 (5): 1144-51.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903.
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.. Oncogene 22 (21): 3307-18.
  • Slominski A, Pisarchik A, Zbytek B, et al. (2003). Functional activity of serotoninergic and melatoninergic systems expressed in the skin.. J. Cell. Physiol. 196 (1): 144-53.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14 (10B): 2121-7.
  • Lin Z, Walther D, Yu XY, et al. (2005). The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse.. Pharmacogenetics 14 (12): 805-11.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature 434 (7034): 724-31.




This article incorporates text from the United States National Library of Medicine, which is in the public domain.Template:Membrane-protein-stub


[[Category:G protein coupled recepto

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