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Changes: 5-HT2B receptor

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{{BioPsy}}
 
{{BioPsy}}
 
{{Wrongtitle|title=5-HT<sub>2B</sub> receptor}}
 
{{Wrongtitle|title=5-HT<sub>2B</sub> receptor}}
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| update_page = yes
 
| require_manual_inspection = no
 
| update_protein_box = yes
 
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{{GNF_Protein_box
 
| image =
 
| image_source =
 
| PDB =
 
| Name = 5-hydroxytryptamine (serotonin) receptor 2B
 
| HGNCid = 5294
 
| Symbol = HTR2B
 
| AltSymbols =; 5-HT(2B); 5-HT2B
 
| OMIM = 601122
 
| ECnumber =
 
| Homologene = 55492
 
| MGIid = 109323
 
| GeneAtlas_image1 = PBB_GE_HTR2B_206638_at_tn.png
 
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
 
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
 
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
 
| Orthologs = {{GNF_Ortholog_box
 
| Hs_EntrezGene = 3357
 
| Hs_Ensembl = ENSG00000135914
 
| Hs_RefseqProtein = NP_000858
 
| Hs_RefseqmRNA = NM_000867
 
| Hs_GenLoc_db =
 
| Hs_GenLoc_chr = 2
 
| Hs_GenLoc_start = 231681199
 
| Hs_GenLoc_end = 231698068
 
| Hs_Uniprot = P41595
 
| Mm_EntrezGene = 15559
 
| Mm_Ensembl = ENSMUSG00000026228
 
| Mm_RefseqmRNA = NM_008311
 
| Mm_RefseqProtein = NP_032337
 
| Mm_GenLoc_db =
 
| Mm_GenLoc_chr = 1
 
| Mm_GenLoc_start = 87930208
 
| Mm_GenLoc_end = 87943141
 
| Mm_Uniprot = Q7TNN4
 
}}
 
}}
 
 
'''5-hydroxytryptamine (serotonin) receptor 2B''', also known as '''HTR2B''', is a [[5-HT2 receptor|5-HT<sub>2</sub> receptor]], but also denotes the human [[gene]] encoding it.<ref name="entrez">{{cite web | title = Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3357| accessdate = }}</ref>
 
'''5-hydroxytryptamine (serotonin) receptor 2B''', also known as '''HTR2B''', is a [[5-HT2 receptor|5-HT<sub>2</sub> receptor]], but also denotes the human [[gene]] encoding it.<ref name="entrez">{{cite web | title = Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3357| accessdate = }}</ref>
   

Latest revision as of 00:22, May 15, 2008

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The correct title of this article is 5-HT2B receptor. It appears incorrectly here because of technical restrictions.


5-hydroxytryptamine (serotonin) receptor 2B, also known as HTR2B, is a 5-HT2 receptor, but also denotes the human gene encoding it.[1]

Function Agonists Antagonists


See alsoEdit

ReferencesEdit

Further readingEdit


  • Raymond JR, Mukhin YV, Gelasco A, et al. (2002). Multiplicity of mechanisms of serotonin receptor signal transduction.. Pharmacol. Ther. 92 (2-3): 179-212.
  • Bonhaus DW, Bach C, DeSouza A, et al. (1995). The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors.. Br. J. Pharmacol. 115 (4): 622-8.
  • Choi DS, Birraux G, Launay JM, Maroteaux L (1994). The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors.. FEBS Lett. 352 (3): 393-9.
  • Kursar JD, Nelson DL, Wainscott DB, Baez M (1994). Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.. Mol. Pharmacol. 46 (2): 227-34.
  • Schmuck K, Ullmer C, Engels P, Lübbert H (1994). Cloning and functional characterization of the human 5-HT2B serotonin receptor.. FEBS Lett. 342 (1): 85-90.
  • Launay JM, Birraux G, Bondoux D, et al. (1996). Ras involvement in signal transduction by the serotonin 5-HT2B receptor.. J. Biol. Chem. 271 (6): 3141-7.
  • Le Coniat M, Choi DS, Maroteaux L, et al. (1996). The 5-HT2B receptor gene maps to 2q36.3-2q37.1.. Genomics 32 (1): 172-3.
  • Kim SJ, Veenstra-VanderWeele J, Hanna GL, et al. (2000). Mutation screening of human 5-HT(2B)receptor gene in early-onset obsessive-compulsive disorder.. Mol. Cell. Probes 14 (1): 47-52.
  • Manivet P, Mouillet-Richard S, Callebert J, et al. (2000). PDZ-dependent activation of nitric-oxide synthases by the serotonin 2B receptor.. J. Biol. Chem. 275 (13): 9324-31.
  • Becamel C, Figge A, Poliak S, et al. (2001). Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.. J. Biol. Chem. 276 (16): 12974-82.
  • Manivet P, Schneider B, Smith JC, et al. (2002). The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis.. J. Biol. Chem. 277 (19): 17170-8.
  • Borman RA, Tilford NS, Harmer DW, et al. (2002). 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro.. Br. J. Pharmacol. 135 (5): 1144-51.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903.
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.. Oncogene 22 (21): 3307-18.
  • Slominski A, Pisarchik A, Zbytek B, et al. (2003). Functional activity of serotoninergic and melatoninergic systems expressed in the skin.. J. Cell. Physiol. 196 (1): 144-53.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14 (10B): 2121-7.
  • Lin Z, Walther D, Yu XY, et al. (2005). The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse.. Pharmacogenetics 14 (12): 805-11.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature 434 (7034): 724-31.




This article incorporates text from the United States National Library of Medicine, which is in the public domain.Template:Membrane-protein-stub


[[Category:G protein coupled recepto

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