Individual differences |
Professional items |
World psychology |
Behavioural genetics ·
Evolutionary psychology ·
Physiological Psychology ·
The correct title of this article is . It appears incorrectly here because of 5-HT 1 receptor technical restrictions.
In the field of
neurochemistry, 5-HT are a subfamily of 1 receptors 5-HT receptors which bind the neurotransmitter and peripheral signal mediator serotonin, also known as 5-hydroxytryptamine (5-HT).
Mode of action Edit
1 receptors are G protein coupled receptors that Gi/Go-coupled. This causes a cellular decrease of cAMP.
Although working basically through the same mechanism, there are several 5-HT
1 receptor subtypes (denoted A-F), each encoded by a separate gene. Furthermore each subtype has a somewhat different tissue distribution and binding preference for synthetic 5-HT 1 agonist and antagonist ligands.
1A acts on the CNS, where it induces neuronal inhibition and controls behaviour, such as sleep, feeding, thermoregulation, aggression, anxiety.
1B acts on the CNS, where it induces presynaptic inhibition and behavioural effects. It also has vascular effects, such as pulmonary vasoconstriction.
1D acts on the CNS, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain. Ergotamine works primarily through the 5-HT1B receptor, since the effect through the 5-HT1D receptor is contrary to the mode of action of ergotamine, i.e. vasoconstriction.
Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP (1994). International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol. Rev. 46 (2): 157–203. ↑
Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). 5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT 1D beta serotonin receptor agonist. J. Med. Chem. 37 (18): 2828–30.
External links Edit