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3-iodothyronamine (T₁AM) is an endogenous thyronamine. T₁AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a G protein-coupled receptor.^{[1] [2]} In rodents, T₁AM causes a rapid drop in body temperature when injected.

T₁AM may be part of a signaling pathway to modulate cardiac function as the compound can induce negative inotropic effects and decrease cardiac output.^[3]

See alsoEdit

• Trace amine

External linksEdit

• MeSH 3-iodothyronamine

References Edit

1. ↑ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D (2004). 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 10 (6): 638-42.
2. ↑ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T (2006). Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 49 (3): 1101-12.
3. ↑ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. (2007). Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function.