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2C is a general name for the family of psychedelic and entheogenic phenethylamines containing methoxy groups on the 2 and 5 positions of the benzene ring. There is also usually a substitute on the 4 position to avoid excessive metabolism and thus be active on the CNS. Most of the currently known 2C's were first synthesized by Alexander Shulgin in the 70's and 80's, and recorded in his book, PiHKAL (Phenethylamines I Have Known And Loved). Dr. Shulgin also invented the term 2C, being an acronym for the 2 carbon atoms between the benzene ring and the amino group (the amphetamine counterparts are sometimes known as 3C's).

2c general structure

General structure of a 2C


Skeletal formula of 2C-T-7


Skeletal formula of 2C-T-21

Nomenclature R3 R4 2D Structure 3D Structure
2C-B HBlank Br Mini 2cb 2C-B-3d-sticks
2C-C H Cl Mini 2cc 2C-C-3d-sticks
2C-D H CH3 Mini 2cd 2C-D-3d-sticks
2C-E H CH2CH3 Mini 2ce 2C-E-3d-sticks
2C-F H F Mini 2cf 2C-F-3d-sticks
2C-G CH3 CH3 Mini 2cg 2C-G-3d-sticks
2C-G-3 (CH2)3 Mini 2cg3
2C-G-4 (CH2)4 Mini 2cg4
2C-G-N (CH)4 Mini 2cgn
2C-H H H Mini 2ch 2C-H-3d-sticks
2C-I H I Mini 2ci 2C-I-3d-sticks
2C-N H NO2 Mini 2cn 2C-N-3d-sticks
2C-O H OCH3 Mini 2co
2C-O-4 H OCH(CH3)2 Mini 2co4 2C-O-4-3d-sticks
2C-P H CH2CH2CH3 Mini 2cp 2C-P-3d-sticks
2C-SE H SeCH3 Mini 2cse 2C-SE-3d-sticks
2C-T H SCH3 Mini 2ct
2C-T-2 H SCH2CH3 Mini 2ct2
2C-T-4 H SCH(CH3)2 Mini 2ct4 2C-T-4-3d-sticks
2C-T-7 H S(CH2)2CH3 Mini 2ct7 2C-T-7-3d-sticks
2C-T-8 H SCH2CH(CH2)2 Mini 2ct8 2C-T-8-3d-sticks
2C-T-9 H SC(CH3)3 Mini 2ct9 2C-T-9-3d-sticks
2C-T-13 H S(CH2)2OCH3 Mini 2ct13 2C-T-13-3d-sticks
2C-T-15 H SCH(CH2)2 2ct15 2C-T-15-3d-sticks
2C-T-17 H SCH(CH3)CH2CH3 2ct17 2C-T-17-3d-sticks
2C-T-21 H S(CH2)2F Mini 2ct21 2C-T-21-3d-sticks
2C-TFM H CF3 Mini 2ctfm

See AlsoEdit

Substituted Amphetamines

External Links Edit

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