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Chemical name 2-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]ethanamine
Chemical formula C11H14F3NO2
Molecular mass  ?
Melting point 260 °C (hydrochloride)
CAS numbers  ?
SMILES COc1cc(CCN)c(cc1C(F)(F)F)OC

2C-TFM is a psychedelic phenethylamine of the 2C family. It was first synthesized in the laboratory of David E. Nichols. It has also been called 2C-CF3, a name derived from the para-trifluoromethyl group it contains. It is sometimes used as a hallucinogen and entheogen.


2C-TFM is a code that represents 4-trifluoromethyl-2,5-dimethoxyphenethylamine. The full name of the chemical is 2-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]ethanamine.


A psychedelic dosage of 2C-TFM is reported to be 3-5mg.


Very little data exists, but some reports suggest 2C-TFM produces hallucinogenic, psychedelic, and entheogenic effects that may last 6-8 hours.


2C-TFM is unscheduled and uncontrolled in the United States, but possession and sales of 2C-TFM will probably be prosecuted under the Federal Analog Act because of its structural similarities to 2C-B and 2C-T-7. However, 2C-TFM, unlike many other phenethylamines, has not been widely sold by internet retailers. In the wake of Operation Web Tryp in July 2004, the issue of possession and sales of 2C-TFM and other similar chemicals will probably be resolved in the courtroom as well the fate of this rare but unique psychedelic. There have been no reported deaths or hospitalizations from 2C-TFM.


The mechanism that produces the hallucinogenic and entheogenic effects of 2C-TFM is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines. 2C-TFM displaced radiolabelled ketanserin from 5-HT2A/C receptors with a Ki of 74.5, as compared to a Ki of 80.9 for the more well known 5-HT2A agonist DOI, indicating similar binding affinity at the receptor.[1]


The toxicity of 2C-TFM is not known.


Sale of 2C-TFM is unknown on the black market. Limited accounts of 2C-TFM can be found on the internet. Outside of David Nichols' lab, the only widely available black market 2C-TFM is known to have been less than 50% pure, with the majority of the impurity being unreacted 2C-I, as well as some undetermined minor constituents.[2]


  1. Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Grudelsky GA, Nash JF. 1-(2,5-Dimethoxy-4(-trifluoromethy1)phenyl-)2-aminopropane: A Potent Serotonin 5-HT2A/C agonist. J. Med. Chem. 1994, 37, 4346-4351.

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