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Chemical name 2-(2,4,5-trimethoxyphenyl)ethanamine
Chemical formula C11H17NO3
Molecular mass  ?
Melting point 187-188 °C
CAS numbers  ?

2C-O (or 2,4,5-trimethoxyphenethylamine) is a phenethylamine of the 2C family. It is also a positional isomer of mescaline and was first synthesized by Jansen in 1931. This chemical is also called 2,4,5-TMPEA. It has structurally similar to the drugs mescaline and 2C-D.


2C-O is in a class of compounds commonly known as phenethylamines, and the full chemical name is 2-(2,4,5-trimethoxyphenyl)ethanamine.


Although not centrally active itself, 2,4,5-TMPEA appeared to potentiate the action of mescaline when employed as pretreatment 45 minutes prior to the administration of mescaline.


The toxicity of 2C-O is not known.


2C-O is unscheduled and unregulated in the United States, however its close similarity in structure to mescaline and 2C-B could potentially subject possession and sale of 2C-O to prosecution under the Federal Analog Act.

2C-O and all other compounds featuring in PiHKAL are Class A drugs in the United Kingdom.

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