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Chemical name 2,5-Dimethoxy-4-methyl-phenethylamine or
Chemical formula C11H17NO2
Molecular mass 195.26 g/mol
Melting point 213 - 214 °C (hydrochloride)
CAS number 24333-19-5
Legal status Class A (UK)

2C-D is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin, sometimes used as an entheogen. The full name of the chemical is 2,5-dimethoxy-4-methyl-phenethylamine. In his book PiHKAL (Phenethylamines I Have Known and Loved), Shulgin lists the dosage range as being from 20 to 80 mg. Lower doses (generally 10mg or less) of 2C-D have been explored as a potential nootropic, albeit with mixed results. 2C-D is generally taken orally, though may be insufflated (ie taken nasally). Insufflating tends to cause intense pain, however, and the dosage level is usual much lower, typically in the region of 1 to 15mg.

Not much information is known about the toxicity of 2C-D, as no major studies have been conducted. According to Shulgin, the effects of 2C-D typically last for 4-6 hours. Shulgin himself referred to this substance as a “pharmacological tofu,” meaning that when mixed with other substances, it can extend or potentiate their effects without coloring the experience too much, in a manner similar to how tofu absorbs the flavors of sauces or spices it is cooked with. Some people have claimed 2C-D is relatively uninteresting on its own, but many other users have strongly disagreed with this assessment and believe instead 2C-D to be a true psychedelic in its own right. Hanscarl Leuner, working in Germany, explored the use of 2C-D under the name LE-25 in psychotherapeutic research.


2C-D is currently unscheduled and uncontrolled in the United States, but the possession and sale of 2C-D could potentially be prosecuted under the Federal Analog Act due to its structural similarities to 2C-B and 2C-T-7.

2C-D and all other compounds featuring in PiHKAL are illegal drugs in the United Kingdom.

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